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cGMP is produced as long as the brain is sending messages down the nerve fibers in the artery. When the brain stops sending the signal, all the cGMP goes away simply because PDE is deactivating it. This really is how the brain turns valves on and off whenever it desires to.
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When the Mind will get aroused, it sends a signal into the penis. Nerve cells from the penis' corpora cavernosa start off generating nitric oxide, which leads to the generation of cGMP.
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The Mind sends indicators to NANC cells inside the artery. The NANC cells release nitric oxide (NO). Nitric oxide acts being a signaling molecule and stimulates an enzyme named guanylate cyclase in close by cells. The guanylate cyclase converts a chemical referred to as GTP into Yet another chemical referred to as cGMP.